Georgia Sfyroera, Ph.D.

Current Position
Senior Research investigatorEducation
Ph.D, University of Patras, Greece, Immunology (2004)M.Sc, University of Patras, Greece, Molecular Biology (2001)
B.Sc, University of Patras, Biology (1998)
Research
Dr. Sfyroera joined Dr. Lambris’s research group in 2001 while she was attending the University of Patras for the completion of her Ph.D. degree. She performed the experiments of her thesis in Dr. Lambris’s laboratory and successfully completed her Ph.D. in 2004. Her thesis centered on the complement evasion mechanisms of the variola and vaccinia viruses. In addition, she made significant contributions to multiple projects that focused on the development and function of various complement inhibitors. Since 2005, Dr. Sfyroera has worked as postdoctoral researcher in the laboratory, and she continues to decipher the mechanisms that pathogenic organisms use to manipulate and control the complement system. Her current research involves studying the interactions between Staphylococcus aureus and the central complement component C3. She is also working on the identification of mutations on the C3 molecule that influence its ability to form the active alternative pathway convertase.
Publications
Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV,.
(2007).
A structural basis for complement inhibition by Staphylococcus aureus.
Nature Immunology
| ![]()
|
![]() |
Park JW, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Shultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW,.
(2004).
Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.
American Journal of Respiratory and Critical Care Medicine
| ![]()
|
![]() |
Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Sfyroera G, Magotti P, Ivanciu L, Lupu C, Mollnes TE, Taylor FB, Kinasewitz G, Lambris JD*, Lupu F*.
(2010).
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis.
Blood
116: 1002-10 *Shared Supervision .
| ![]()
|
![]() |
Wu YQ, Qu H, Sfyroera G, Tzekou A, Kay BK, Nilsson B, Nilsson Ekdahl K, Ricklin D*, Lambris JD*.
(2011).
Protection of nonself surfaces from complement attack by factor h-binding peptides: implications for therapeutic medicine.
Journal of Immunology
186: 4269-77. * Shared Supervision . Additional Links: erratum.
| ![]()
|
![]() |
Melillo D, Sfyroera G, De Santis R, Graziano R, Marino R, Lambris JD, Pinto MR.
(2006).
First identification of a chemotactic receptor in an invertebrate species: structural and functional characterization of Ciona intestinalis C3a receptor..
Journal of immunology (Baltimore, Md. : 1950)
| ![]()
|
![]() |