Reviews & Chapters

Reviews & Chapters

Mastellos DC, Reis ES, Ricklin D, Smith RJ, Lambris JD. (2017). Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery.. Trends in Immunology 38: 383-394. pubmedlogo PDF File

Olsen I, Lambris JD, Hajishengallis G. (2017). Porphyromonas gingivalis disturbs host-commensal homeostasis by changing complement function. Journal of Oral Microbiology 9: 1340085. pubmedlogo PDF File

Hajishengallis G, Hajishengallis E, Kajikawa T, Wang B, Yancopoulou D, Ricklin D, Lambris JD. (2016). Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application. Seminars in immunology 28: 285-291. pubmedlogo PDF File

Hajishengallis G, Lambris JD. (2016). More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation. Immunological Reviews 274: 233-244. pubmedlogo PDF File

Mastellos DC, Reis ES, Yancopoulou D, Hajishengallis G, Ricklin D, Lambris JD. (2016). From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage. Immunobiology 221: 1046-57. pubmedlogo PDF File

Mastellos DC, Ricklin D, Hajishengallis E, Hajishengallis G, Lambris JD. (2016). Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention. Molecular Oral Microbiology 31: 3-17. pubmedlogo PDF File

Ricklin D, Lambris JD. (2016). Complement therapeutics.. Seminars in Immunology 28: 205-7. pubmedlogo PDF File

Ricklin D, Lambris JD. (2016). Therapeutic control of complement activation at the level of the central component C3.. Immunobiology 221: 740-6. pubmedlogo PDF File

Ricklin D, Lambris JD. (2016). New milestones ahead in complement-targeted therapy. Seminars in Immunology 28: 208-22. pubmedlogo PDF File

Ricklin D, Lambris JD. (2016). Preformed mediators of defense-Gatekeepers enter the spotlight. Immunological Reviews 274: 5-8. pubmedlogo PDF File

Ricklin D, Reis ES, Lambris JD. (2016). Complement in disease: a defence system turning offensive.. Nature Reviews. Nephrology 12: 383-401. pubmedlogo PDF File

Ricklin D, Reis ES, Mastellos DC, Gros P, Lambris JD. (2016). Complement component C3 - The "Swiss Army Knife" of Innate Immunity and host defense. Immunological Reviews 274: 33-58. pubmedlogo PDF File

Schmidt CQ, Lambris JD, Ricklin D. (2016). Protection of host cells by complement regulators. Immunological Reviews 274: 152-171. pubmedlogo PDF File

Hajishengallis G, Maekawa T, Abe T, Hajishengallis E, Lambris JD. (2015). Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches. Advances in Experimental Medicine and Biology 865: 57-74. pubmedlogo PDF File

Kollias G, Lambris JD. (2015). A 'rule of 3' to revive Greek science, research and innovation.. Nature immunology 16: 1206-8. pubmedlogo PDF File

Kourtzelis I, Magnusson PU, Kotlabova K, Lambris JD, Chavakis T. (2015). Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions. Advances in Experimental Medicine and Biology 865: 171-88. pubmedlogo PDF File

Mastellos DC, Yancopoulou D, Kokkinos P, Huber-Lang M, Hajishengallis G, Biglarnia AR, Lupu F, Nilsson B, Risitano AM, Ricklin D, Lambris JD. (2015). Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. European Journal of Clinical Investigation 45: 423-40. pubmedlogo PDF File

Reis ES, Mastellos DC, Yancopoulou D, Risitano AM, Ricklin D, Lambris JD. (2015). Applying complement therapeutics to rare diseases. Clinical immunology (Orlando, Fla.) 161: 225-240. pubmedlogo PDF File

Hajishengallis G, Chavakis T, Hajishengallis E, Lambris JD. (2014). Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis. Journal of Leukocyte Biology :. pubmedlogo PDF File

Lupu F, Keshari RS, Lambris JD, Coggeshall KM. (2014). Crosstalk between the coagulation and complement systems in sepsis. Thrombosis Research 133 Suppl 1: S28-31. pubmedlogo PDF File

Mastellos DC, Deangelis RA, Lambris JD. (2014). Inducing and characterizing liver regeneration in mice: Reliable models, essential. Current Protocols in Mouse Biology 3: 141-170. pubmedlogo PDF File

Mastellos DC, Ricklin D, Yancopoulou D, Risitano A, Lambris JD. (2014). Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape.. Expert Review of Hematology 7: 583-98. pubmedlogo PDF File

Hajishengallis G, Abe T, Maekawa T, Hajishengallis E, Lambris JD. (2013). Role of complement in host-microbe homeostasis of the periodontium. Seminars in Immunology 25: 65-72. pubmedlogo PDF File

Hajishengallis G, Mantovani A, Moretta A, Lambris JD. (2013). Aegean reflections on innate immunity. Nature Immunology 14: 1025-9. pubmedlogo PDF File

Lambris JD. (2013). Complement: More than killing. Seminars in Immunology 25: 1. pubmedlogo PDF File

Mastellos DC, Deangelis RA, Lambris JD. (2013). Complement-triggered pathways orchestrate regenerative responses throughout phylogenesis. Seminars in Immunology 25: 29-38. pubmedlogo PDF File

Phieler J, Garcia-Martin R, Lambris JD, Chavakis T. (2013). The role of the complement system in metabolic organs and metabolic diseases. Seminars in Immunology 25: 47-53. pubmedlogo PDF File

Pio R, Ajona D, Lambris JD. (2013). Complement inhibition in cancer therapy. Seminars in Immunology 25: 54-64. pubmedlogo PDF File

Pio R, Corrales L, Lambris JD. (2013). The role of complement in tumor growth. Advances in Experimental Medicine and Biology 772: 229-62. pubmedlogo PDF File

Ricklin D, Lambris JD. (2013). Complement in immune and inflammatory disorders: pathophysiological mechanisms. Journal of Immunology 190: 3831-8. pubmedlogo PDF File

Ricklin D, Lambris JD. (2013). Complement in immune and inflammatory disorders: therapeutic interventions. Journal of Immunology 190: 3839-47. pubmedlogo PDF File

Brekke OL, Waage C, Christiansen D, Fure H, Qu H, Lambris JD, Osterud B, Nielsen EW, Mollnes TE. (2012). The Effects of Selective Complement and CD14 Inhibition on the E. coli-Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood. Advances in Experimental Medicine and Biology 734: 123-36. pubmedlogo PDF File

Deangelis RA, Reis ES, Ricklin D, Lambris JD. (2012). Targeted complement inhibition as a promising strategy for preventing inflammatory complications in hemodialysis. Immunobiology 217: 1097-105. pubmedlogo PDF File

Hajishengallis G, Lambris JD. (2012). Complement and dysbiosis in periodontal disease. Immunobiology 217: 1111-6. pubmedlogo PDF File

Hajishengallis G, Lambris JD. (2012). Complement-targeted therapeutics in periodontitis. Advances in Experimental Medicine and Biology 734: 197-206. pubmedlogo PDF File

Oikonomopoulou K, Reis ES, Lambris JD. (2012). Complement system and its role in immune responses. eLS 15-Aug-12. PDF File

Ricklin D, Lambris JD. (2012). Progress and trends in complement therapeutics. Advances in Experimental Medicine and Biology 734: 1-22. pubmedlogo PDF File

Ricklin D, Reis ES, Lambris JD. (2012). A sweet spot to control complement-induced inflammation. Nature Medicine 18: 1340-1. pubmedlogo PDF File

Schoengraf P, Lambris JD, Recknagel S, Kreja L, Liedert A, Brenner RE, Huber-Lang M, Ignatius A. (2012). Does complement play a role in bone development and regeneration?. Immunobiology 218: 1-9. pubmedlogo PDF File

Christiansen D, Brekke OL, Stenvik J, Lambris JD, Espevik T, Mollnes TE. (2011). Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood. Advances in Experimental Medicine and Biology 946: 237-51. pubmedlogo PDF File

Ekdahl KN, Lambris JD, Elwing H, Ricklin D, Nilsson PH, Teramura Y, Nicholls IA, Nilsson B. (2011). Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies. Advanced Drug Delivery Reviews 63: 1042-50. pubmedlogo PDF File

Garcia BL, Ramyar KX, Ricklin D, Lambris JD, Geisbrecht BV. (2011). Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins. Advances in Experimental Medicine and Biology 946: 113-33. pubmedlogo PDF File

Hajishengallis G, Krauss JL, Liang S, McIntosh ML, Lambris JD. (2011). Pathogenic microbes and community service through manipulation of innate immunity. Advances in Experimental Medicine and Biology 946: 69-85. pubmedlogo PDF File

Hajishengallis G, Lambris JD. (2011). Microbial manipulation of receptor crosstalk in innate immunity. Nature Reviews Immunology 11: 187-200. Additional Links: At a glance, Supplementary info. pubmedlogo PDF File

Oikonomopoulou K, Ricklin D, Ward PA, Lambris JD. (2011). Interactions between coagulation and complement-their role in inflammation. Seminars in immunopathology 34: 151-65. pubmedlogo PDF File

Chi ZL, Yoshida T, Lambris JD, Iwata T. (2010). Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration. Advances in Experimental Medicine and Biology 703: 127-35. pubmedlogo PDF File

Hajishengallis G, Lambris JD. (2010). Crosstalk pathways between Toll-like receptors and the complement system. Trends in Immunology 31: 154-63. pubmedlogo PDF File

Hajishengallis G, Lambris JD. (2010). Illuminating the latest advances in innate immunity on the island of the sun god. Expert Review of Clinical Immunology 6: 875-8 . pubmedlogo PDF File

Nilsson B, Korsgren O, Lambris JD, Ekdahl KN. (2010). Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?. Trends in Immunology 31: 32-8. pubmedlogo PDF File

Ricklin D, Hajishengallis G, Yang K, Lambris JD. (2010). Complement: a key system for immune surveillance and homeostasis. Nature Immunology 11: 785-97 . pubmedlogo PDF File

Krauss JL, Potempa J, Lambris JD, Hajishengallis G. (2009). Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host. Periodontology 2000 52: 141-62. pubmedlogo PDF File

Markiewski MM, DeAngelis RA, Lambris JD. (2009). Complexity of complement activation in sepsis. Journal of Cellular and Molecular Medicine 12: 2245-54. pubmedlogo PDF File

Markiewski MM, Lambris JD. (2009). Unwelcome Complement. Cancer Research 69: 6367-70. pubmedlogo PDF File

Markiewski MM, Lambris JD. (2009). Is complement good or bad for cancer patients? A new perspective on an old dilemma. Trends in Immunology 30: 286-92. pubmedlogo PDF File

Qu H, Ricklin D, Lambris JD. (2009). Recent developments in low molecular weight complement inhibitors. Molecular Immunology 47: 185-95. pubmedlogo PDF File

Amara U, Rittirsch D, Flierl M, Bruckner U, Klos A, Gebhard F, Lambris JD, Huber-Lang M. (2008). Interaction between the coagulation and complement system. Advances in Experimental Medicine and Biology 632: 71-9. pubmedlogo PDF File

Lambris JD, Ricklin D, Geisbrecht BV. (2008). Complement evasion by human pathogens. Nature reviews Microbiology 6: 132-42. pubmedlogo PDF File

Ricklin D, Lambris JD. (2008). Compstatin: a complement inhibitor on its way to clinical application. Advances in Experimental Medicine and Biology 632: 273-92. pubmedlogo PDF File

Markiewski MM, Lambris JD. (2007). The role of complement in inflammatory diseases from behind the scenes into the spotlight. American Journal of Pathology 171:715-727 . pubmedlogo PDF File

Markiewski MM, Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD. (2007). Complement and coagulation: strangers or partners in crime?. Trends in Immunology 28:184-192 . pubmedlogo PDF File

Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD. (2007). The role of complement in biomaterial-induced inflammation. Molecular Immunology 44 :82-94 . pubmedlogo PDF File

Pinto MR, Melillo D, Giacomelli S, Sfyroera G, Lambris JD. (2007). Ancient origin of the complement system: Emerging invertebrate models. Adv Exp Med Biol 598:372-388 . pubmedlogo PDF File

Ricklin D, Lambris JD. (2007). Exploring the complement interaction network using surface plasmon resonance. Adv Exp Med Biol 598:260-278 . pubmedlogo PDF File

Ricklin D, Lambris JD. (2007). Complement-targeted therapeutics. Nature Biotechnology 25: 1265-75. pubmedlogo PDF File

Schuster MC, Chen H, and Lambris JD. (2007). Hydrogen/Deuterium exchange mass spectrometry: Potential for investigating innate immunity proteins. Adv Exp Med Biol 598:407-417 . pubmedlogo PDF File

Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF. (2007). New Approaches to the Treatment of Dense Deposit Disease. Journal of the American Society of Nephrology 18:2447-2456 . pubmedlogo PDF File

DeAngelis RA, Markiewski MM, Lambris JD. (2006). Liver regeneration: a link to inflammation through complement.. Advances in Experimental Medicine and Biology 586: 17-34 . pubmedlogo PDF File

Mastellos D, Lambris JD. (2006). Cross-disciplinary research stirs new challenges into the study of the structure, function and systems biology of complement. Advances in Experimental Medicine and Biology 586: 1-16. pubmedlogo

Reca R, Wysoczynski M, Yan J, Lambris JD, Ratajczak MZ. (2006). The role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow. Advances in experimental medicine and biology 586: 35-51 . pubmedlogo PDF File

Tsonis PA, Lambris JD, Del Rio-Tsonis K. (2006). To regeneration...with complement.. Advances in Experimental Medicine and Biology 586: 63-70 . pubmedlogo PDF File

Morikis, D., Floudas, C. A., and Lambris, J. D. (2005). Structure-based integrative computational and experimental approach for the optimization of drug design. Computational Science - Iccs 2005, Pt 2 3515:680-688. PDF File

Appel GB, Cook HT, Hageman G, Jennette JC, Kashgarian M, Kirschfink M, Lambris JD, Lanning L, Lutz HU, Meri S, Rose NR, Salant DJ, Sethi S, Smith RJ, Smoyer W, Tully HF, Tully SP, Walker P, Welsh M, Würzner R, Zipfel PF. (2005). Membranoproliferative glomerulonephritis type II (dense deposit disease): an update.. Journal of the American Society of Nephrology 16: 1392-403 . pubmedlogo PDF File

Markiewski MM, DeAngelis RA, Lambris JD. (2005). Liver inflammation and regeneration: two distinct biological phenomena or parallel pathophysiologic processes?. Molecular Immunology 43: 45-56 . pubmedlogo PDF File

Mastellos D, Andronis C, Persidis A, Lambris JD. (2005). Novel biological networks modulated by complement. Clinical Immunology 115: 225-35 . pubmedlogo PDF File

Mastellos D, Germenis AE, Lambris JD. (2005). Complement: an inflammatory pathway fulfilling multiple roles at the interface of innate immunity and development.. Current drug targets. Inflammation and allergy 4: 125-7 . pubmedlogo PDF File

Mastellos D, Lambris JD. (2005). Intergrating Innate Immunity into a Global 'Systems' Context: the Complement Paradigm Shift. Systems Biology   . PDF File

Morikis D, Lambris JD. (2005). The building blocks of the complement system. The Structural Biology of The Complement System pp:1-18 .

Morikis D, Lambris JD. (2005). Structure, dynamics activity and function of compstatin and design of more potent analogs. The Structural Biology of the Complement System pp:317-340 .

Morikis,D. and Lambris,J.D. (2005). Structure of anaphylatoxins C3a and C5a. The structural Biology of the Complement System pp:161-178.

Floudas C A, Klepeis JL, Lambris JD, Morikis D. (2004). De Novo Protein Design" An Interplay of Global Optimization, Mixed-Integer Optimization and Experiments. Proceedings of FOCAPD pp:133-146 . PDF File

Holland MC, Morikis D, Lambris JD. (2004). Synthetic small-molecule complement inhibitors.. Current Opinion in Investigational Drugs 5: 1164-73 . pubmedlogo PDF File

Holland MCH, Lambris JD. (2004). Complement. Nature Encyclopedia of Life Sciences   . PDF File

Mastellos D, Morikis D, Strey C, Holland MC, Lambris JD. (2004). From atoms to systems: a cross-disciplinary approach to complement-mediated functions. Molecular Immunology 41: 153-64 . pubmedlogo PDF File

Morikis D, Lambris JD. (2004). Physical methods for structure, dynamics and binding in immunological research. Trends in Immunology 25: 700-7 . pubmedlogo PDF File

Morikis D, Soulika AM, Mallik B, Klepeis JL, Floudas CA, Lambris JD. (2004). Improvement of the anti-C3 activity of compstatin using rational and combinatorial approaches. Biochemical Society Transactions 32: 28-32 . pubmedlogo PDF File

Sarrias MR, Sahu A, Lambris JD. (2004). Characterization of the interactions of complement receptor 2 with its ligands iC3b,C3d and EBV glycoprotein gp350/220. Biacore Journal 4:14-17 . PDF File

Mastellos D, Morikis D, Isaacs SN, Holland MC, Strey CW, Lambris JD. (2003). Complement: structure, functions, evolution, and viral molecular mimicry.. Immunologic Research 27: 367-86 . pubmedlogo PDF File

Morikis, D. and Lambris, J. D. (2002). Structural aspects and design of low-molecular-mass complement inhibitors. Biochemical Society Transactions 30:1026-1036. PDF File

Holland MC, Lambris JD. (2002). The complement system in teleosts. Fish & Shellfish Immunology 12: 399-420 . pubmedlogo PDF File

Mastellos D, Lambris JD. (2002). Complement: more than a 'guard' against invading pathogens?. Trends in Immunology 23: 485-91 . pubmedlogo PDF File

Mollnes TE, Song WC, Lambris JD. (2002). Complement in inflammatory tissue damage and disease. Trends in Immunology 23: 61-4 . pubmedlogo PDF File

Sahu, A. and Lambris, J. D. (2002). Novel anti-factor D monoclonal antibody inhibits complement and leukocyte activation in a baboon model of cardiopulmonary bypass - Invited commentary. Annals of Thoracic Surgery 74 (2):362. Additional Links: Invited Commentary to Articles by Undar et al. PDF File

Sahu A, Lambris JD. (2001). Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunological Reviews 180: 35-48 . pubmedlogo PDF File

Zarkadis IK, Mastellos D, Lambris JD. (2001). Phylogenetic aspects of the complement system. Developmental and Comparative Immunology 25: 745-62 . pubmedlogo PDF File

Sahu A, Lambris JD. (2000). Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics. Immunopharmacology 49: 133-48 . pubmedlogo PDF File

Sahu A, Morikis D, Lambris JD. (2000). Complement inhibitor targeting C3,C4, and C5. Therapeutic interventions in the complement system 4:75-112 . PDF File

Song WC, Sarrias MR, Lambris JD. (2000). Complement and innate immunity. Immunopharmacology 49: 187-98 . pubmedlogo PDF File

Lambris JD, Reid KB, Volanakis JE. (1999). The evolution, structure, biology and pathophysiology of complement. Immunology Today 20: 207-11. pubmedlogo PDF File

Morikis D, Sahu A, Moore WT, Lambris JD. (1999). Design, structure, function and application of compstatin in Bioactive peptides in Drug discovery and design:medical aspects. IOS Press pp:235-246 . PDF File

Sunyer JO, Lambris JD. (1999). Evolution and diversity of the complement system of poikilothermic vertebrates.. Immunological Reviews 166: 39-57 . pubmedlogo PDF File

Sunyer,J.O. and Lambris,J.D. (1999). Complement. Encyclopedia of Life Sciences
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Lambris,J.D., Sahu,A., Wetsel,R.A. (1998). C3, C4 and C5:Genes, structure, and functions. The Human Complement System in Health and Disease pp:83-118. PDF File

Sahu A, Sunyer JO, Moore WT, Sarrias MR, Soulika AM, Lambris JD. (1998). Structure, functions, and evolution of the third complement component and viral molecular mimicry. Immunologic Research 17: 109-21 . pubmedlogo PDF File

Sunyer JO, Zarkadis IK, Lambris JD. (1998). Complement diversity: a mechanism for generating immune diversity?. Immunology Today 19: 519-23. pubmedlogo PDF File

Lambris,J.D., Mavroidis,M. and Sunyer,J.O. (1994). Phylogeny of third component of complement, C3. New Aspects of complement structure and function 2:15-34. PDF File

Lambris, J. D. (1993). Chemistry, biology and phylogeny of C3. Complement Profiles 1:16-45. PDF File

Lambris JD, Becherer JD, Servis C, Alsenz J. (1993). Use of synthetic peptides in exploring and modifying complement reactivities. Activators and inhibitors of complement activation, Kluwer Academic Press, Lancaster pp:201-232 . PDF File

Tsoukas CD, Lambris JD. (1993). Expression of EBV/C3d receptors on T cells: biological significance.. Immunology Today 14: 56-9 . pubmedlogo PDF File

Alsenz J, Becherer JD, Nilsson B, Lambris JD. (1990). Structural and functional analysis of C3 using monoclonal antibodies.. Current Topics in Microbiology and Immunology 153: 235-48 . pubmedlogo PDF File

Becherer JD, Alsenz J, Lambris JD. (1990). Molecular aspects of C3 interactions and structural/functional analysis of C3 from different species.. Current Topics in Microbiology and Immunology 153: 45-72 . pubmedlogo PDF File

Becherer JD, Alsenz J, Servis C, Myones BL, Lambris JD. (1989). Cell surface proteins reacting with activated complement components.. Complement and Inflammation 6: 142-65 . pubmedlogo PDF File

Lambris JD. (1989). The multifunctional role of C3, the third component of complement.. Immunology Today 9: 387-93 . pubmedlogo PDF File

Lambris JD, Müller-Eberhard HJ. (1987). The multifunctional role of C3: structural analysis of its interactions with physiological ligands.. Molecular Immunology 23: 1237-42 . pubmedlogo PDF File

Lambris JD, Tsokos GC. (1986). The biology and pathophysiology of complement receptors.. Anticancer Research 6: 515-23 . pubmedlogo PDF File